Barcelona beat Villarreal CF 3-2 at Camp Nou on February 1 (matchday 21) thanks to goals from Neymar, Rafinha and Messi. On the 30th, Barcelona won the Spanish Cup final against Athletic Bilbao at Camp Nou with a score of 3 to 1 (two goals from Lionel Messi, one of which was legendary, and one from Neymar). The best attendance of the season took place on March 22, 2015 with 98,760 spectators during the 28th day of the Spanish championship against Real Madrid. Barça, who had opened the scoring by Luis Suárez in the 59th minute (his 19th goal of the season and his 13th in La Liga), rests on his laurels which costs him the equalizer in the 86th minute. This is Barca's 20th unbeaten game in all competitions, the best streak since Luis Enrique's arrival at Barca. On May 29, the club announced the arrival of Ernesto Valverde. On August 9, the club announced that Neymar would be out of action for 15 days after being diagnosed with parotitis (he suffers from mumps).

On August 29, the club announced the departure of Spanish midfielder Denis Suárez (previously loaned to Sevilla FC for 2 years) to Villarreal CF. On February 28, Barça beat Sevilla FC 2 to 1 at Camp Nou with a magnificent free kick from Lionel Messi and a decisive goal from Gerard Piqué (26th day of the championship). On June 25, Catalan winger Gerard Deulofeu, in return for a loan from Sevilla FC, was transferred to Everton FC for €6 million. Upon his return to Mexico, he continued to teach and served in the Ministry of Public Education. On June 12, Jesús Vallejo and Borja Mayoral, on loan to the Bundesliga for the 2016-2017 season, returned to Real. It follows the 2014-2015 season which saw Barça win the league, the Spanish Cup and the Champions League. This season follows the 2014–15 season which saw Real Madrid win the UEFA Super Cup and the Club World Cup; this season is also the club's 85th in La Liga. Barcelona end the season with a record of 60 games played, 50 wins, 4 draws and 6 losses.

Like the previous season, Barcelona eliminated Manchester City. On July 25, Barça lost 3 to 1 against a much better prepared Manchester United at Levi's Stadium near San Francisco (Barcelona's only goal was scored by Rafinha). Barcelona ended February with a 3-1 win over Granada CF (matchday 25). Parodi Ligure is a town and comune in the province of Alexandria in the Piedmont region of Italy. On August 23, for the last friendly match of the pre-season, neymar jersey Real Madrid face Fiorentina as part of the Santiago Bernabéu Trophy in Madrid. Finalist of the Europa League Conference in 2023 with ACF Fiorentina. In 2018, punctuated by a third Champions League in a row and a World Cup final, Luka Modrić became the first Croatian player to win the Golden Ball. On December 17, deprived of Messi victim of renal colic and Neymar physically impaired at the Nissan Stadium in Yokohama, Barcelona beat 3 to 0 (triple of Luis Suárez) the Chinese of Guangzhou Evergrande of Luiz Felipe Scolari in the semi-final of the competition. On February 3, Barcelona pulverized Valencia 7-0 at Camp Nou in the semi-final of the Spanish Cup with four goals from Luis Suárez and a hat-trick from Lionel Messi at the end of a totally controlled match.

On February 7, Barça won 2-0 at Levante UD (23rd day of the championship). On the 14th, Barça won the victory on the ground of the newly promoted SD Eibar thanks to a double from Messi (27th day of the championship). On the 28th, Barcelona largely beat Getafe CF 6-0 with a first half of great beauty during which Barça scored five goals (34th day of the championship). This specific picture is often enriched with systemic signs having nothing to do with gland damage, but arising from the autoimmune nature of the disease. On July 3, the Iberian right-back Martín Montoya is loaned for two seasons to Inter Milan. On July 21, the club recruited young Portuguese midfielder André Gomes from Valencia for €35 million. On July 30, Neymar, Daniel Alves, Lionel Messi and Javier Mascherano join the Barcelona squad. On 5 August, in the 50th edition of the Joan Gamper Trophy at Camp Nou in front of 94,400 spectators, Barcelona beat AS Roma 3–0 with goals from Neymar, Messi and Rakitić. On September 20, led by Marc Bartra, Neymar and Lionel Messi, Barça regaled again against Levante UD at Camp Nou (4th day of the championship).